반응 #427402

반응 방정식

5-bromopyridin-3-ol

benzyl bromide

→

3-(benzyloxy)-5-bromopyridine

용매

toluene

반응 조건

후처리

1. 1
   여과the reaction mixture was filtered
2. 2
   세척eluting with ethyl acetate
3. 3
   농축The filtrate was concentrated en vacuo into a residue that
4. 4
   기타was purified by a COMBIFLASH® system (ISCO)

실험 절차

A solution of 5-bromopyridin-3-ol (1.0 eq.), benzyl bromide (1.2 eq.), and silver carbonate (1.3 eq.) in toluene (0.1 M) was heated to 50° C. and stirred for 18 hours. After cooling to room temperature, the reaction mixture was filtered, eluting with ethyl acetate. The filtrate was concentrated en vacuo into a residue that was purified by a COMBIFLASH® system (ISCO) using 20% ethyl acetate in hexane to give 3-(benzyloxy)-5-bromopyridine.

출처