반응 #42738

반응 방정식

2-(4-chlorophenyl)-1-(3,4-difluoro-2-hydroxy-phenyl)-4-methyl-pentane-1,3-dione

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title compound

3-(4-Chlorophenyl)-7,8-difluoro-2-isopropyl-chromen-4-one

용매

acetic acid

HCl

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled to room temperature
2. 2
   workup.ADDITIONpoured onto ice-water
3. 3
   추출extracted with methylene chloride
4. 4
   세척The organic layer is washed with saturated sodium hydrogen carbonate solution
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타evaporated to dryness in vacuo

실험 절차

A mixture of 2-(4-chlorophenyl)-1-(3,4-difluoro-2-hydroxy-phenyl)-4-methyl-pentane-1,3-dione (3.65 g, 10.3 mmol) in acetic acid (36 ml) and concentrated HCl solution (2 ml) is stirred at 140° C. for 3 h. The reaction mixture is cooled to room temperature, poured onto ice-water and extracted with methylene chloride. The organic layer is washed with saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate and evaporated to dryness in vacuo to afford the title compound as a brown solid.

출처