반응 #42727

반응 방정식

4-hydroxyphenethyl alcohol

potassium carbonate

1,3 dibromopropane

→

title compound

수율 77.3%

2-[4-(3-Bromopropoxy)phenyl]ethanol

수율 77.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   여과filtered
3. 3
   농축concentrated under vacuum
4. 4
   기타The resulting oil was purified by silica gel chromatography
5. 5
   workup.ADDITIONa mixture of 4:1 hexanes and ethyl acetate

실험 절차

To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.

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