반응 #426989

반응 방정식

2,6-dichloro-4-trifluoromethylpyridine

NaOH MeOH

→

2-methoxy-6-chloro-4-trifluoromethylpyridine

수율 99.9%

용매

methanol

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   기타overnight
3. 3
   추출The reaction mixture was extracted with pentane
4. 4
   농축the extract was concentrated in vacuo

실험 절차

To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.

출처