반응 #42634

반응 방정식

2-Thiophenecarbonylchloride

tert-butyl-1-piperazinecarboxylate

→

solids

수율 88.1%

4-(Thiophene-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

수율 88.1%

용매

pyridine

반응 조건

후처리

1. 1
   여과the precipitate was filtered
2. 2
   세척washed several times with water
3. 3
   기타dried

실험 절차

2-Thiophenecarbonylchloride (2.04 g, 1.49 mL) was added to a solution of tert-butyl-1-piperazinecarboxylate (2.5 g, 13.4 mmol) and DMAP (20 mg) in pyridine (15 mL) at 0° C. under N2 atmosphere and stirred at room temperature for overnight. The mixture was poured into ice water, the precipitate was filtered, washed several times with water, and dried to yield white solids (3.5 g, 88%). Mp 76° C. 1H NMR (DMSO-d6): δ 1.42 (s, 12H), 3.40 (m, 4H), 3.61 (m, 4H), 7.12 (m, 1H), 7.43 (d, J=4.1 Hz, 1H), 7.77 (d, J=4.8 Hz, 1H). EIMS m/z 297 (M+1), 319 (M+23). Anal. (C14H20N2O3S) C, H, N.

출처