반응 #426037

반응 방정식

(S)-benzyl 3-(tert-butoxycarbonyl(methyl)amino)pyrrolidine-1-carboxylate

→

(S)-tert-butyl methyl(pyrrolidin-3-yl)carbamate

수율 99.4%

용매

ethanol

methanol

반응 조건

후처리

1. 1
   기타The mixture was evacuated
2. 2
   기타evacuated
3. 3
   여과The suspension was filtered through a pad of Celite
4. 4
   세척washed with methanol (60 mL)
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

To a suspension of 5% Pd/C (4.60 g, 2.16 mmol) in ethanol (40 mL) was added slowly a solution of (S)-benzyl 3-(tert-butoxycarbonyl(methyl)amino)pyrrolidine-1-carboxylate (7.2 g, 21.6 mmol) in methanol (20 mL). The mixture was evacuated and backfilled with nitrogen and then evacuated and backfilled with hydrogen then stirred under a hydrogen atmosphere for 2 hours. The suspension was filtered through a pad of Celite and washed with methanol (60 mL). The filtrate was concentrated under reduced pressure to afford (S)-tert-butyl methyl(pyrrolidin-3-yl)carbamate (4.3 g, 99%).

출처