반응 #425705

반응 방정식

water

3-bromo-2,6-dichloropyridine

sodium methoxide

→

title compound

수율 93.2%

3-bromo-6-chloro-2-methoxypyridine

수율 93.2%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타the organic was evaporated
2. 2
   여과The resulting suspension was filtered
3. 3
   세척the pad was washed with water for several times
4. 4
   기타The pad was dried

실험 절차

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

출처