반응 #42560

반응 방정식

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester

HCl

dioxane

methanol

→

solid

수율 106.0%

BOC-acetylene

수율 106.0%

반응 조건

후처리

1. 1
   기타The volatiles were evaporated in vacuo
2. 2
   workup.ADDITIONDioxane (20 mL) was added
3. 3
   기타the mixture was evaporated in vacuo

실험 절차

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester (2.34 g, 5.13 mmol) was treated with 4N HCl in dioxane (15.8 mL, 63.3. mmol). The resulting heterogeneous mixture was treated with methanol (10 mL) whereupon it became homogeneous over 30 min. The volatiles were evaporated in vacuo. Dioxane (20 mL) was added and the mixture was evaporated in vacuo to produce a white solid (2.33 g, 106%).

출처