반응 #42452

반응 방정식

2-Chloroisonicotinonitrile

dipropylamine

→

title compound

2-(Dipropylamino)isonicotinonitrile

반응 조건

후처리

1. 1
   기타The mixture was removed
2. 2
   온도from heat
3. 3
   온도cooled to room temperature
4. 4
   기타The dipropylamine was removed under reduced pressure
5. 5
   기타the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent

실험 절차

2-Chloroisonicotinonitrile (1.0 g) and dipropylamine (10 mL) were placed in a sealed heavy wall tube and heated to 100° C. for 18 h. The mixture was removed from heat and cooled to room temperature. The dipropylamine was removed under reduced pressure and the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent to give 1.06 g of the title compound: MS (ESI+) for C12H17N3 m/z 204.1 (M+H)+.

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