반응 #4239

반응 방정식

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

수율 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

수율 92.8%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타the volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   온도chilled
4. 4
   여과filtered
5. 5
   기타dried

실험 절차

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

출처