반응 #42335

ord-da90b0ae5963488daffc62f844ba69b8

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타A 250 ml round bottom flask equipped with magnetic stir bar
  2. 2
    온도reflux condenser, and N2 inlet
  3. 3
    온도The solution was refluxed for 4 hours
  4. 4
    농축then concentrated in vacuo
  5. 5
    기타vacuum dried overnight

실험 절차

A 250 ml round bottom flask equipped with magnetic stir bar, reflux condenser, and N2 inlet was charged with 9.2 g methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate in 50 ml acetic acid and 50 ml conc. HCl. The solution was refluxed for 4 hours then concentrated in vacuo. The residue was chased with toluene (2×) then vacuum dried overnight to yield 7.8 g of the desired 3-[(1-propylbutyl)sulfonyl]alanine HCl salt.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07727997B2uspto-grants-2010_06