반응 #4228

반응 방정식

2,6-dimethoxy-5-nitro-4-pyrimidinamine

2-carbomethoxybenzenesulfonyl isocyanate

→

title compound

수율 90.6%

2-[[(2,6-Dimethoxy-5-nitropyrimidin-4-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester

수율 90.6%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The solvent was then evaporated under reduced pressure
2. 2
   여과The solid was then collected by filtration
3. 3
   세척washed with ether
4. 4
   기타dried in an oven

실험 절차

A solution of 0.2 g (1.0 mmol) of 2,6-dimethoxy-5-nitro-4-pyrimidinamine and 0.6 g (2.4 mmol) of 2-carbomethoxybenzenesulfonyl isocyanate in 15 ml of methylene chloride was stirred at ambient temperature and pressure for 12 hours under anhydrous conditions. The solvent was then evaporated under reduced pressure. The residue was stirred in n-butyl chloride (70 ml). The solid was then collected by filtration, washed with ether and then dried in an oven to afford 0.4 g of the title compound, m.p. 150°-152° dec.

출처