반응 #42261

반응 방정식

3-tert-butyl-1-methyl-6,6-di(p-tolyl)fulvene

fluorene

water

n-butyl lithium hexane

→

aimed compound

(3-tert-butyl-5-methyl-cyclopentadienyl)(fluorenyl)di(p-tolyl)methane

용매

diethylether

diethyl ether

반응 조건

후처리

1. 1
   기타In a 200 ml three-necked flask equipped with a magnetic stirrer chip and three-way cock
2. 2
   기타To the reaction solution, a solution prepared
3. 3
   workup.ADDITIONwas added
4. 4
   workup.STIRRINGstirred
5. 5
   온도under reflux for 10 days
6. 6
   기타the organic layer was separated
7. 7
   workup.ADDITIONby adding diethyl ether
8. 8
   세척washed with distilled water and saturated brine
9. 9
   건조The organic phase was dried with anhydrous magnesium sulfate
10. 10
    여과the drying agent was filtered off
11. 11
    workup.DISTILLATIONThe solvent was distilled off from the filtrate under reduced pressure
12. 12
    기타to give a red brown liquid
13. 13
    기타The red brown liquid was purified by a column chromatography
14. 14
    workup.DISTILLATIONthe developing solvent was distilled off under reduced pressure
15. 15
    기타The residue product was re-crystallized
16. 16
    기타dried under reduced pressure

실험 절차

In a 200 ml three-necked flask equipped with a magnetic stirrer chip and three-way cock thoroughly purged with nitrogen, 0.373 g of fluorene (2.25 mmol) was dissolved in 60 ml of dehydrated diethylether in a nitrogen atmosphere. To the reaction solution, 1.6 ml of a n-butyl lithium/hexane solution (1.56M: 2.50 mmol) was gradually added dropwise in an ice bath and thereafter stirred at room temperature over night. To the reaction solution, a solution prepared by dissolving 1.10 g of 3-tert-butyl-1-methyl-6,6-di(p-tolyl)fulvene (3.36 mmol) in 60 ml of dehydrated diethyl ether was added and stirred under reflux for 10 days. To the reaction mixture, 30 ml of distilled water was gradually added dropwise in an ice bath, and thereafter the organic layer was separated by adding diethyl ether and washed with distilled water and saturated brine. The organic phase was dried with anhydrous magnesium sulfate and then the drying agent was filtered off. The solvent was distilled off from the filtrate under reduced pressure to give a red brown liquid. The red brown liquid was purified by a column chromatography using 80 g of silica gel (developing solvent: n-hexane) and the developing solvent was distilled off under reduced pressure. The residue product was re-crystallized using hexane and dried under reduced pressure, and thereby the aimed compound was obtained in an amount of 0.140 g (0.282 mmol) as a pale yellow solid (yield: 13%).

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