반응 #4223

반응 방정식

2-(4-chlorophenylethyl)-2-tert.-butyl-oxirane

1,2,4-triazole

→

1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentane-3-ol

수율 53.3%

용매

ethanol

반응 조건

후처리

1. 1
   온도to cool
2. 2
   농축was concentrated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ether
4. 4
   세척the solution was washed three times with water
5. 5
   건조once with sodium chloride solution, dried over sodium sulphate
6. 6
   농축concentrated
7. 7
   기타The residue was chromatographed over a silica gel column (mobile phase: methylene chloride/ethyl acetate 1:1)

실험 절차

A solution of 17.9 g (0.075 mole) of 2-(4-chlorophenylethyl)-2-tert.-butyl-oxirane and 6.9 g (0.1 mole) of 1,2,4-triazole in 30 ml of ethanol was heated in a bomb tube at 150° C. for 20 hours. The reaction solution was allowed to cool and was concentrated. The residue was dissolved in ether and the solution was washed three times with water and once with sodium chloride solution, dried over sodium sulphate and concentrated. The residue was chromatographed over a silica gel column (mobile phase: methylene chloride/ethyl acetate 1:1). 12.3 g (53.2% of theory) of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentane-3-ol were obtained as a viscous oil.

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