반응 #42218

반응 방정식

(±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]propane-1,2-diol

p-toluenesulfonyl chloride

→

(±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]-2-hydroxypropyl 4-methylbenzenesulfonate

수율 80.2%

용매

pyridine

반응 조건

실험 절차

Treatment of (±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]propane-1,2-diol (24 g, 0.07 mol) with p-toluenesulfonyl chloride (14 g, 0.074 mol) in pyridine (600 mL) generally according to the procedure described for Intermediate 18 gave 27.9 g (80%) of (±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]-2-hydroxypropyl 4-methylbenzenesulfonate as a white solid. mp 85-87° C.; Anal. calcd. for C27H25ClO5S: C, 65.25; H, 5.07. Found: C, 65.37; H, 4.97.

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