반응 #42099

반응 방정식

product

N-(7-(2,4-dichlorophenyl)-6-(4-chlorophenyl)-1,2-dihydro-1,3-dimethyl-2-oxo-1,8-naphthyridin-4-yl)-N-propionylpropionamide

methanol

Cs2CO3

→

title compound

N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1,3-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]propanamide

용매

THF

EtOAc

반응 조건

후처리

1. 1
   세척washed with saturated aqueous NaHCO3 solution
2. 2
   기타The concentrated residue was purified by flash chromatography on silica gel with an EtOAc/hexane gradient elution

실험 절차

To the product of step A (1.56 g) in THF (12 mL) was added methanol (3 mL) and Cs2CO3. The reaction stirred overnight at room temperature before it was diluted with EtOAc and washed with saturated aqueous NaHCO3 solution. The concentrated residue was purified by flash chromatography on silica gel with an EtOAc/hexane gradient elution affording the title compound. HPLC/MS: 499.8 (M+1), 501.8 (M+3); Rt=3.95 min.

출처