반응 #42098

반응 방정식

product

N-[3-(bromoacetyl)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

NaOAc

→

1-acetyl-8-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-3-hydroxy-5-methyl-1,5-dihydro-4H-pyrrolo[3,2-c]-1,8-naphthyridin-4-one

용매

DMF

water

EtOAc

반응 조건

후처리

1. 1
   세척washed with saturated aqueous NaHCO3 and brine
2. 2
   기타The concentrated residue was purified by flash chromatography on silica gel with a gradient elution of 0-100% EtOAc in hexane affording the title compound

실험 절차

To the product of Step A (25 mg) was added NaOAc (60 mg) in DMF (2.5 mL) and water (0.3 mL) at room temperature. The reaction stirred overnight and was diluted with EtOAc, washed with saturated aqueous NaHCO3 and brine. The concentrated residue was purified by flash chromatography on silica gel with a gradient elution of 0-100% EtOAc in hexane affording the title compound. HPLC/MS: 512.0 (M+1), 514.0 (M+3); Rt=4.18 min.

출처