반응 #42097

반응 방정식

product

2-{[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]amino}-2-oxoethyl acetate

Cs2CO3

→

N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-2-hydroxyacetamide

용매

CH2Cl2

methanol

EtOAc

반응 조건

후처리

1. 1
   세척The reaction was washed with brine and 10% aqueous NaHSO4 solution
2. 2
   기타The concentrated residue was purified by flash chromatography on silica gel gradient
3. 3
   세척eluted with 0-65% EtOAc in hexane affording the title compound

실험 절차

To the product of EXAMPLE 33 (77 mg) in CH2Cl2 (2 mL) was added Cs2CO3 (43.7 mg) in methanol (1 mL). The reaction stirred at room temperature for 2.5 hours before diluting with EtOAc. The reaction was washed with brine and 10% aqueous NaHSO4 solution. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-65% EtOAc in hexane affording the title compound. HPLC/MS: 530.1 (M+1), 532.1 (M+3); Rt=3.85 min.

출처