반응 #420933

반응 방정식

2-[3-(benzyloxy)propyl]-3-methyl-3H-imidazo[4,5-b]pyridine

formic acid

→

title compound

수율 81.7%

3-(3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)propan-1-ol

수율 81.7%

용매

methanol

반응 조건

후처리

1. 1
   온도was refluxed for 6 hr
2. 2
   여과the catalyst was filtered off
3. 3
   농축The obtained filtrate was concentrated under reduced pressure
4. 4
   기타The residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)

실험 절차

A mixture of 2-[3-(benzyloxy)propyl]-3-methyl-3H-imidazo[4,5-b]pyridine (1.8 g), 20% palladium hydroxide on carbon (2.35 g, containing water (50%)), and formic acid (8.45 mL) in methanol (84.5 mL) was refluxed for 6 hr. The mixture was allowed to cool to room temperature, and the catalyst was filtered off. The obtained filtrate was concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.0 g).

출처