반응 #420932

반응 방정식

methanol

dimethylsulfuric acid

2-[3-(benzyloxy)propyl]-3H-imidazo[4,5-b]pyridine

sodium hydride

→

title compound

2-[3-(benzyloxy)propyl]-3-methyl-3H-imidazo[4,5-b]pyridine

용매

DMF

반응 조건

후처리

1. 1
   온도cooling for 30 min
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 17 hr
3. 3
   농축the mixture was concentrated under reduced pressure
4. 4
   기타The residue was purified by silica gel column chromatography (ethyl acetate/methanol)

실험 절차

Under an argon atmosphere, to a solution of 2-[3-(benzyloxy)propyl]-3H-imidazo[4,5-b]pyridine (2 g) in DMF (40 mL) was added 60% sodium hydride (0.299 g), and the mixture was stirred under ice-cooling for 30 min. Then, dimethylsulfuric acid (0.75 mL) was added, and the mixture was stirred at room temperature for 17 hr. To the reaction mixture was added methanol (5 mL), and the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (1.2 g).

출처