반응 #4209

반응 방정식

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

수율 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

수율 60.4%

용매

acetone

반응 조건

후처리

1. 1
   여과The reaction was filtered hot
2. 2
   기타to remove the sodium iodide
3. 3
   기타a precipitate formed in the cold filtrate which
4. 4
   기타was collected
5. 5
   세척washed with cold acetone
6. 6
   기타to give
7. 7
   기타upon drying

실험 절차

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

출처