반응 #42082

반응 방정식

product

N-[3-Acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

THF

NaBH4

→

N-[6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-3-(1-hydroxyethyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

용매

MeOH

반응 조건

후처리

1. 1
   기타were combined at room temperature
2. 2
   농축After 7 minutes the reaction was concentrated
3. 3
   workup.DISSOLUTIONdissolved in EtOAc
4. 4
   세척before washing with water
5. 5
   건조drying (Na2SO4)
6. 6
   기타The concentrated residue was purified by preparative TLC (silica gel)
7. 7
   세척eluted with EtOAc affording the title compound

실험 절차

The product of Example 1 (65 mg), THF (3 mL), MeOH (0.33 mL) and NaBH4 (9.6 mg) were combined at room temperature. After 7 minutes the reaction was concentrated and then dissolved in EtOAc before washing with water and drying (Na2SO4). The concentrated residue was purified by preparative TLC (silica gel) eluted with EtOAc affording the title compound. HPLC/MS: 515.9 (M+1), 517.9 (M+3); Rt=3.68 min.

출처