반응 #42044

반응 방정식

N,N-dimethylformamide dimethylacetal

5-acetylpyrimidine

diisopropyl ether

→

objective compound

수율 68.0%

3-(dimethylamino)-1-(5-pyrimidinyl)-2-propen-1-one

수율 68.0%

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도at reflux for 15 hours
3. 3
   온도After the reaction solution was air-cooled
4. 4
   여과the deposited crystal was collected by filtration

실험 절차

6.01 g of N,N-dimethylformamide dimethylacetal was added to 1.54 g of 5-acetylpyrimidine (Khim. Geterotsikl. Soedim., 1981, (7), 958-962) and the mixture was heated at reflux for 15 hours. After the reaction solution was air-cooled, a small amount of diisopropyl ether was added and the deposited crystal was collected by filtration to obtain 1.52 g of the objective compound as reddish brown crystals.

출처