반응 #42041

반응 방정식

3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid

thionyl chloride

→

3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoyl chloride hydrochloride

반응 조건

후처리

1. 1
   기타obtained in the step 7
2. 2
   workup.DISTILLATIONwas distilled off under reduced pressure
3. 3
   workup.ADDITIONthe operation of adding of toluene to the residue
4. 4
   기타followed by azeotropic removal of thionyl chloride

실험 절차

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid obtained in the step 7 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

출처