반응 #420296

반응 방정식

4-isothiocyanatobenzenesulfonamide

bis(pyridin-2-ylmethyl)amine

→

4-(3,3-bis(pyridin-2-ylmethyl)thioureido)benzenesulfonamide

용매

acetonitrile

반응 조건

후처리

1. 1
   기타a white precipitate formed
2. 2
   여과The solid was filtered
3. 3
   세척washed with acetonitrile
4. 4
   기타dried
5. 5
   기타to afford MIP-1138 as

실험 절차

To a suspension of 4-isothiocyanatobenzenesulfonamide (401 mg, 1.87 mmol) in dry acetonitrile (10 mL) was added bis(pyridin-2-ylmethyl)amine (373 mg, 1.87 mmol). The reaction mixture went clear and a white precipitate formed. The solid was filtered, washed with acetonitrile and dried to afford MIP-1138 as a white sold (710 mg, 92%). 1H NMR (400 MHz, DMSO-d6) δ 11.18 (s, 1H), 8.61 (br, 2H), 7.79-7.64 (m, 6H), 7.34-7.25 (m, 6H), 5.14 (br, 4H); (M+H)+ (414).

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