반응 #420295

반응 방정식

4-(2-aminoethyl)benzene sulfonamide

succinic anhydride

→

desired product

4-oxo-4-(4-sulfamoylphenethylamino)butanoic Acid

용매

dioxane

반응 조건

후처리

1. 1
   온도the slurry was heated to a reflux overnight
2. 2
   여과The white solid was filtered
3. 3
   세척washed with cold dioxane

실험 절차

4-(2-aminoethyl)benzene sulfonamide (1 g, 5.0 mmol) and succinic anhydride (500 mg, 5.0 mmol) were combined in a round bottom flask containing dioxane (100 mL) and the slurry was heated to a reflux overnight. The white solid was filtered and washed with cold dioxane to yield the desired product (1.4 g, 4.6 mol, 92%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 8.00 (s, 1H), 7.71 (d, J=8.1 Hz, 2H), 7.36 (d, J=8.1 Hz, 2H), 7.38 (s, 1H), 3.26 (m, 2H), 2.75 (t, J=7.1 Hz, 2H), 2.5 (m, 2H), 2.3 (t, J=7.1 Hz, 2H); (M+H)+ (301).

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