반응 #41998

반응 방정식

N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide

morpholine

→

title compound

수율 83.0%

N-{3-[5-Fluoro-1-(3-morpholin-4-yl-propyl)-indan-1-yl]-1H-indol-7-yl}-methanesulfonamide

수율 83.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타Remove the volatiles under high vacuum
2. 2
   workup.DISSOLUTIONdissolve the residue in dichloromethane
3. 3
   workup.ADDITIONadd solid potassium carbonate
4. 4
   여과filter
5. 5
   농축concentrate in vacuo
6. 6
   기타Purify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes

실험 절차

Combine N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide (65 mg, 0.13 mmol) and morpholine (2 ml) in anhydrous tetrahydrofuran (2.5 ml) and stir at room temperature under nitrogen overnight. Remove the volatiles under high vacuum, dissolve the residue in dichloromethane, add solid potassium carbonate, stir for ten minutes, filter, and concentrate in vacuo. Purify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes to obtain the title compound as a white solid (50 mg, 83%). LC-MS m/z 472.2 (M++1).

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