반응 #419779

반응 방정식

5-Ethoxycarbonylfuran-2-ylacetic acid tert-butyl ester

5-ethoxycarbonylfuran-2-ylacetic acid tert-butyl ester

Hydrochloric acid

→

title compound

수율 24.2%

5-tert-butoxycarbonylmethyl-2-furancarboxylic acid

수율 24.2%

용매

sodium hydroxide

tetrahydrofuran

반응 조건

후처리

1. 1
   기타purified by high performance liquid chromatography
2. 2
   기타freeze-dried

실험 절차

5-Ethoxycarbonylfuran-2-ylacetic acid tert-butyl ester (0.37 g, 1.46 mmol) obtained in step 2 was dissolved in tetrahydrofuran (2 mL), dissolved in 1N aqueous sodium hydroxide solution (1.5 mL), and the mixture was stirred overnight. 1N Hydrochloric acid (1.5 mL) was added to the reaction mixture, and the mixture was neutralized, purified by high performance liquid chromatography and freeze-dried to give the title compound (80 mg).

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