반응 #419772

반응 방정식

sodium hydroxide

5-(2-tert-Butoxycarbonylpropyl)furan-2-carboxylic acid methyl ester

5-(2-tert-butoxycarbonylpropyl)-furan-2-carboxylic acid methyl ester

hydrochloric acid

→

title compound

수율 102.5%

5-(2-tert-butoxycarbonylpropyl)-furan-2-carboxylic acid

수율 102.5%

용매

methanol

tetrahydrofuran

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척washed successively with water and saturated brine
3. 3
   건조After drying over anhydrous magnesium sulfate
4. 4
   여과the drying agent was filtered off
5. 5
   기타the solvent was evaporated

실험 절차

5-(2-tert-Butoxycarbonylpropyl)furan-2-carboxylic acid methyl ester (1.0 g, 3.76 mmol) obtained in step 1 was dissolved in tetrahydrofuran (4.5 mL) and methanol (3 mL), 1N aqueous sodium hydroxide solution (4.5 mL) was added, and the mixture was stirred overnight. The mixture was neutralized with 1N hydrochloric acid, extracted with ethyl acetate, and washed successively with water and saturated brine. After drying over anhydrous magnesium sulfate, the drying agent was filtered off, and the solvent was evaporated to give the title compound (0.98 g).

출처