반응 #41967

반응 방정식

5-fluoro-indan-1-one

pyrazole

potassium carbonate

→

title compound

수율 73.0%

5-Pyrazol-1-yl-indan-1-one

수율 73.0%

용매

dimethyl sulfoxide

ether

반응 조건

후처리

1. 1
   세척wash with water (2×)
2. 2
   건조dry over anhydrous sodium sulfate
3. 3
   농축concentrate

실험 절차

Combine 5-fluoro-indan-1-one (1.02 g, 6.79 mmol), pyrazole (0.46 g, 6.79 mmol), and potassium carbonate (1.03 g, 7.47 mmol, 1.10 equivalents) in dimethyl sulfoxide (5 ml) in a sealed tube and heat to 100° C. for 48 hours. Cool to room temperature, dilute with ether, wash with water (2×), dry over anhydrous sodium sulfate, and concentrate to obtain the title compound as a brown solid (0.98 g, 73%). LC-MS m/z 199.1 (M++1).

출처