반응 #41965

반응 방정식

triphenylphosphine

3-bromopropionic acid

ether

→

title compound

수율 68.5%

(2-Carboxy-ethyl)-triphenyl-phosphonium bromide

수율 68.5%

용매

acetonitrile

반응 조건

후처리

1. 1
   여과Filter solids
2. 2
   세척rinse with ether
3. 3
   기타dry solids under high vacuum

실험 절차

Reflux a solution of triphenylphosphine (91.3 g, 348 mmol, 1.05 equivalents) and 3-bromopropionic acid (50.7 g, 331 mmol) in acetonitrile (250 ml) for three hours, allow to sit at room temperature overnight. Add ether (400 ml) and cool in the freezer for two hours. Filter solids, rinse with ether, and dry solids under high vacuum to obtain the title compound (94.1 g, 68%). NMR (400 MHz, CDCl3): δ 3.15 (m, 2H), 3.73 (m, 2H), 7.69-7.83 (m, 15H).

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