반응 #41956

반응 방정식

Chloroacetaldehyde diethyl acetal

potassium benzoate

potassium bromide

DMF

→

compound

수율 34.1%

2-benzoyloxyacetaldehyde Diethyl Acetal

수율 34.1%

용매

ethyl acetate

water

반응 조건

후처리

1. 1
   온도by refluxing
2. 2
   여과After filtration
3. 3
   세척the organic layer was washed with water (30 mL)
4. 4
   건조was dried over anhydrous sodium sulfate
5. 5
   여과Subsequent filtration and vacuum concentration

실험 절차

Chloroacetaldehyde diethyl acetal (2.00 g), potassium benzoate (1.91 g), potassium bromide (0.30 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (30 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration, the organic layer was washed with water (30 mL) and was dried over anhydrous sodium sulfate. Subsequent filtration and vacuum concentration yielded the target compound (0.97 g) in a yield of 31%.

출처