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6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

2-fluoroethylamine hydrochloride

→

title compound

수율 95.0%

N-(2-Fluoro-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide

수율 95.0%

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실험 절차

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 2-fluoroethylamine hydrochloride instead of methylamine, to the title compound (109 mg, 95%) which was obtained as a white solid. MS: m/e=356.3 [M+H]+.

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