반응 #41925

반응 방정식

Trifluoroacetic acid

tert-butyl 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate

→

2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

수율 29.0%

반응 조건

후처리

1. 1
   기타Trifluoroacetic acid was removed under vacuum
2. 2
   세척the resulting solids were washed with water (3×), ether (3×)
3. 3
   기타dried in a vacuum oven at 50° C.

실험 절차

Trifluoroacetic acid (1.00 ml, 13 mmol) was added to tert-butyl 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate (0.021 g, 0.07 mmol) and stirred at room temperature for 15 minutes. Trifluoroacetic acid was removed under vacuum and the resulting solids were washed with water (3×), ether (3×) and dried in a vacuum oven at 50° C. to afford 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid in 29% yield.

출처