반응 #41917

반응 방정식

trimethyl borate

magnesium

potassium carbonate

2-bromo-4-fluoro-1-(tetrahydropyran-2-yloxy)benzene

→

5-Fluoro-2-(tetrahydropyran-2-yloxy)benzeneboronic acid

용매

THF

water

THF

반응 조건

후처리

1. 1
   workup.ADDITIONOn completion of addition
2. 2
   세척The organic phase was washed with saturated sodium chloride, solution
3. 3
   농축(1×500 ml) and subsequently concentrated to dryness
4. 4
   기타The yield was 428.2 g (1.78 mol), and the product was obtained as a waxy solid which
5. 5
   기타was used in the following stage without further purification

실험 절차

48.6 g (2.00 mol) of magnesium and 510 g (1.85 mol) of 2-bromo-4-fluoro-1-(tetrahydropyran-2-yloxy)benzene in 1250 ml of THF were used to prepare a Grignard reagent. This Grignard reagent was slowly added dropwise at −78° C. to a mixture of 241.6 ml (2.00 mol) of trimethyl borate in 500 ml of THF. On completion of addition, the reaction mixture was allowed to warm to room temperature and was hydrolyzed by addition of 100 ml of saturated potassium carbonate solution and 1000 ml of water. The organic phase was washed with saturated sodium chloride, solution. (1×500 ml) and subsequently concentrated to dryness. The yield was 428.2 g (1.78 mol), and the product was obtained as a waxy solid which contained varying proportions of boronic anhydride and borinic acids and was used in the following stage without further purification.

출처