반응 #418480

반응 방정식

2-bromo-3-(3,5-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one

2-Bromo-3-(3,5-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one

6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one

4-(trifluoromethyl)phenylboronic acid

→

title compound

수율 69.0%

3-(3,5-Difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-2-(4-(trifluoromethyl)phenyl)-1H-inden-1-one

수율 69.0%

반응 조건

후처리

1. 1
   기타being purified by prep HPLC (CH3CN/H2O=7:3)

실험 절차

The procedure of Step 7 of Example 1 was repeated except for using 2-bromo-3-(3,5-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one obtained in Step 1 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, and 4-(trifluoromethyl)phenylboronic acid instead of 3-pyridinylboronic acid, and being purified by prep HPLC (CH3CN/H2O=7:3) to obtain the title compound (69%).

출처