반응 #418479

반응 방정식

2-bromo-6-[2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy]-3-[4-(trifluoromethyl)phenyl]-1H-inden-1-one

2-Bromo-6-[2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy]-3-[4-(trifluoromethyl)phenyl]-1H-inden-1-one

6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one

5-pyrimidinylboronic acid

→

title compound

수율 14.0%

6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-2-(pyrimidin-5-yl)-3-(4-(trifluoromethyl)phenyl)-1H-inden-1-one

수율 14.0%

반응 조건

후처리

1. 1
   기타being purified by prep HPLC (CH3CN/H2O=7:3)

실험 절차

The procedure of Step 7 of Example 1 was repeated except for using 2-bromo-6-[2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy]-3-[4-(trifluoromethyl)phenyl]-1H-inden-1-one obtained in Step 1 of Example 47 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, and 5-pyrimidinylboronic acid instead of 3-pyridinylboronic acid, and being purified by prep HPLC (CH3CN/H2O=7:3) to obtain the title compound (14%).

출처