반응 #418472

반응 방정식

6-(2-morpholinoethoxy)-2-bromo-3-(3,5-difluorophenyl)-1H-inden-1-one

6-(2-Morpholinoethoxy)-2-bromo-3-(3,5-difluorophenyl)-1H-inden-1-one

6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one

5-pyrimidinylboronic acid

→

title compound

수율 36.0%

6-(2-morpholinoethoxy)-3-(3,5-difluorophenyl)-2-(pyrimidin-5-yl)-1H-inden-1-one

수율 36.0%

반응 조건

후처리

1. 1
   기타being purified by prep HPLC (CH3CN/H2O=7:3)

실험 절차

The procedure of Step 7 of Example 1 was repeated except for using 6-(2-morpholinoethoxy)-2-bromo-3-(3,5-difluorophenyl)-1H-inden-1-one obtained in Step 6 of Example 36 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 5-pyrimidinylboronic acid instead of 3-pyridinylboronic acid, and being purified by prep HPLC (CH3CN/H2O=7:3) to obtain the title compound (36%).

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