반응 #418460

반응 방정식

6-(2-morpholinoethoxy)-2-bromo-3-(4-chlorophenyl)-1H-inden-1-one

6-(2-Morpholino ethoxy)-2-bromo-3-(4-chlorophenyl)-1H-inden-1-one

6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one

4-(trifluoromethyl)phenyboronic acid

→

title compound

수율 14.0%

6-(2-morpholinoethoxy)-3-(4-chlorophenyl)-2-(4-(trifluoromethyl)phenyl)-1H-inden-1-one

수율 14.0%

반응 조건

후처리

1. 1
   기타being purified by prep HPLC (CH3CN/H2O=7:3)

실험 절차

The procedure of Step 7 of Example 1 was repeated except for using 6-(2-morpholinoethoxy)-2-bromo-3-(4-chlorophenyl)-1H-inden-1-one obtained in Step 6 of Example 28 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 4-(trifluoromethyl)phenyboronic acid instead of 3-pyridinylboronic acid, and being purified by prep HPLC (CH3CN/H2O=7:3) to obtain the title compound (14%).

출처