반응 #41817

반응 방정식

(4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone

fumaric acid

→

crude title compound

(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone Mono-fumarate Salt

용매

THF

THF

반응 조건

후처리

1. 1
   온도The resulting suspension was cooled to 0° C.
2. 2
   여과the resulting precipitate was collected by filtration
3. 3
   세척washed with THF (20 mL)
4. 4
   기타dried in a vacuum oven at 65° C. for 20 h

실험 절차

To a THF solution (40 mL) of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone (3.0 g, 9.0 mmol) were added THF (40 mL) and fumaric acid (3.3 g, 28.4 mmol). The resulting mixture was heated to 60° C. and stirred for 0.5 h. The resulting suspension was cooled to 0° C. and the resulting precipitate was collected by filtration, washed with THF (20 mL), and dried in a vacuum oven at 65° C. for 20 h to yield crude title compound as a white solid.

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