반응 #41807

반응 방정식

1

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

→

2

3-Fluoro-4-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine

용매

methanol

반응 조건

후처리

1. 1
   기타The was reaction
2. 2
   온도maintained for 1 h
3. 3
   여과The reaction was filtered through Celite
4. 4
   세척the remained solids were washed with methanol
5. 5
   농축The combined organics were concentrated

실험 절차

A reaction tube was charged with a suspension of 1 (270 mg, 0.9 mmol) and Lindlar catalyst (192 mg, 10 mol %) in methanol (5 mL), and was then placed on a Parr shaker. The was reaction pressurized with H2 (60 psi) and maintained for 1 h. The reaction was filtered through Celite and the remained solids were washed with methanol. The combined organics were concentrated to give 2 as a brown semi-solid which was carried forward without further purification LCMS m/z 273.3 (MH+), tR=1.56 min.

출처