반응 #417970

반응 방정식

Acetic acid

25b

1-bromo-4-nitro-2-(2-phenoxy-ethoxy)-benzene

→

aniline

수율 84.0%

4-bromo-3-(2-phenoxy-ethoxy)-phenylamine

수율 84.0%

용매

ethanol

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   기타the crude was purified by flash column chromatography

실험 절차

Acetic acid (1.068 mL, 18 mmol) was added to the mixture of 25b (600 mg, 1.8 mmol) and zinc dust (1.157 g, 18.0 mmol) in ethanol (10 mL) at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hrs. The mixture was filtered, the solvent distilled off under reduced pressure and the crude was purified by flash column chromatography to obtain the aniline 25c in 84% yield.

출처