반응 #417969

반응 방정식

BBr3

1-bromo-2-methoxy-4-nitrobenzene

→

desired compound

수율 65.0%

2-bromo-5-nitro-phenol

수율 65.0%

용매

DCM

반응 조건

후처리

1. 1
   기타The mixture was quenched with water
2. 2
   추출extracted with ethyl acetate (3×20 mL)
3. 3
   기타The combined extracts were dried
4. 4
   기타the crude was purified by flash column chromatography

실험 절차

BBr3 (8.58 mL of 1.0M solution, 8.6 mmol) was added to the DCM (10 mL) solution of 1-bromo-2-methoxy-4-nitrobenzene (1.0 g, 4.3 mmol) at 0° C. The reaction mixture was warmed to room temperature and stirred overnight. The mixture was quenched with water and extracted with ethyl acetate (3×20 mL). The combined extracts were dried and the crude was purified by flash column chromatography to get the desired compound as pale brown powder in 65% yield (600 mg).

출처