반응 #417964

반응 방정식

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

수율 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

수율 93.0%

용매

acetic acid

반응 조건

후처리

1. 1
   온도the reaction was refluxed for 5 mins
2. 2
   여과It was filtered off
3. 3
   세척washed with water (10 mL)
4. 4
   기타dried

실험 절차

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

출처