반응 #417962

반응 방정식

N-(4-Butyl-3-(2-phenoxyethoxy)phenyl)acetamide

KOH

→

title compound

수율 80.0%

4-butyl-3-(2-phenoxyethoxy)aniline

수율 80.0%

용매

water

ethanol

water

DCM

반응 조건

후처리

1. 1
   온도to reflux for 18 hrs
2. 2
   세척The organic layer was washed with water (×2)
3. 3
   건조dried over sodium sulfate
4. 4
   기타The crude compound was purified further via flash chromatography with hexane:ethyl acetate (1:1)

실험 절차

N-(4-Butyl-3-(2-phenoxyethoxy)phenyl)acetamide (132 g, 0.41 mol) was dissolved in ethanol (897 mL) and water (104 mL). KOH (312 g, 5.57 mol) was added at 0° C. and the solution was allowed to reflux for 18 hrs. Upon completion the reaction was cooled to room temperature and diluted with 2 L of water and 2 L of DCM. The organic layer was washed with water (×2) and dried over sodium sulfate. The crude compound was purified further via flash chromatography with hexane:ethyl acetate (1:1) to obtain the title compound in 80% yield (92 g) as a pink solid.

출처