반응 #417951

반응 방정식

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

용매

DCM

반응 조건

후처리

1. 1
   기타The reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   여과the resulting mixture is filtered
4. 4
   건조dried over MgSO4
5. 5
   여과filtered again
6. 6
   기타the solvent is removed in vacuo

실험 절차

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

출처