반응 #417948

반응 방정식

2-bromo-5-hydroxypyridine

1-bromopropane

K2CO3

→

2-Bromo-5-propoxy-pyridine

용매

ACN

반응 조건

후처리

1. 1
   온도at reflux over night
2. 2
   기타Afterwards the reaction is quenched by the addition of water
3. 3
   추출extracted with TBME
4. 4
   건조dried over MgSO4
5. 5
   여과filtered
6. 6
   기타the solvent is removed in vacuo
7. 7
   기타The crude product is purified by column chromatography (silica gel, PE/EtOAc)

실험 절차

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

출처