반응 #417946

반응 방정식

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

반응 조건

후처리

1. 1
   기타The reaction is quenched by the addition of water
2. 2
   추출extracted with DCM
3. 3
   건조layers are dried over MgSO4
4. 4
   여과filtered

실험 절차

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

출처