반응 #417944

반응 방정식

BOC2O

(S)-1-(4-bromophenyl)ethylamine

Na2CO3

→

(S)-tert-Butyl 1-(4-bromophenyl)ethylcarbamate

용매

THF

DCM

반응 조건

후처리

1. 1
   workup.ADDITIONThen the mixture is poured onto water
2. 2
   workup.STIRRINGstirred for additional 20 min
3. 3
   기타The layers are separated
4. 4
   세척layer is washed with water (2×)
5. 5
   건조dried over Na2SO4
6. 6
   여과filtered
7. 7
   기타the solvent is removed in vacuo

실험 절차

To 150 g (735 mmol) (S)-1-(4-bromophenyl)ethylamine in 2 L DCM are added 459 mL (918 mmol) of an aq. Na2CO3 solution (c=2 mol/L). To this mixture a solution of 164 g (749 mmol) BOC2O in 350 mL THF is added dropwise at r.t. and stirring is continued for 1 h. Then the mixture is poured onto water and stirred for additional 20 min. The layers are separated, the org. layer is washed with water (2×), dried over Na2SO4, filtered and the solvent is removed in vacuo.

출처