반응 #417943

반응 방정식

(S)-1-(4-bromophenyl)ethylamine

acetic anhydride

→

(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

용매

DCM

반응 조건

후처리

1. 1
   기타Then the cooling is removed
2. 2
   세척Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. 3
   건조layer is dried over MgSO4
4. 4
   여과filtered
5. 5
   기타the solvent is removed in vacuo

실험 절차

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

출처